Tyra Biosciences, Inc. (Nasdaq: TYRA) is a clinical-stage biotechnology company focused on developing next-generation precision medicines that target large opportunities in FGFR biology. The Company's in-house precision medicine platform, SNÅP, enables the rapid and precise refinement of structural drug design through iterative molecular SNÅPshots that help predict genetic alterations most likely to cause acquired resistance to existing therapies. TYRA's initial focus is on applying its accelerated small molecule drug discovery engine to develop therapies in targeted oncology and genetically defined conditions. TYRA is based in Carlsbad, CA.

Position Overview:

Tyra Biosciences, Inc. is seeking a highly motivated Sr. Director, Clinical Scientist to make impactful contributions to oncology drug discovery projects targeting disease areas with high unmet medical need. The successful candidate will be highly organized, self-motivated, and thrive in a dynamic, cross-functional start-up environment.

This position requires broad knowledge and experience across the clinical development spectrum, specifically late-stage development. This individual will contribute to the development, planning, and execution of Tyra’s clinical research strategy. A clinical scientist provides support for programs as assigned by compound, phase, or therapeutic area.

Job Responsibilities

• Must have experience working in all phases of clinical research (Phases 1-3); phase 3 experience must be large, controlled, global studies
• Work cross-functionally to contribute to the design and development of clinical research protocols for assigned clinical research studies
• Maintain a thorough understanding of the protocol, including the history of all previous versions
• Conduct and collaborate on all data review/generation activities that include but are not limited to ongoing and final clinical data review, query resolution to ensure consistent, quality data
• Ability to access/review raw data in the clinical study database and generate GCP appropriate queries as needed.
• Contribute to and collaborate with Data Management on the development of case report forms/electronic data capture (EDC), including weighing in on edit checks, tolerance limits and other aspects related to developing and updating a study database.
• Contribute to and collaborate with Biostatics/Programming on the development of/review of tables, listings and figures (TLFs) for assigned clinical studies. The TLFs may be outputs for different needs (i.e., DSUR/IB, abstracts). Additional collaboration with other members of Tyra may be necessary to determine the proper output requirements.
• Identify clinical data trends; provide trends and escalate questions to study physician.
• Attend study related/compound related meetings to understand study/compound strategy; contribute as needed to the program strategy, clinical development plans, and corporate materials, in collaboration with the program’s Asset Lead
• Lead the development of the informed consent forms; also responsible for any updates to the risk section following DSUR/IB updates
• Contribute to the development and review of Investigator Brochures, annual reports and other Health Authority submissions (i.e., Request for Information).
• Attend and present clinical updates on assigned compounds/programs as requested to internal personnel (i.e., senior management) or external (i.e., Steering Committee).
• Develop relationships with appropriate consultants and External Experts to gain and apply insights on protocol design and compound strategy
• Contribute to the development of abstracts, posters, oral presentations, and manuscripts for external publications
• Contribute to or lead process improvement initiatives
• Maintain updated knowledge of competitive landscape with regard to assets similar to Tyra’s compounds, as well as evolving standards of care for indications of interest
• Collaborate and liaise with internal cross-functional team members
• Meet with lead PIs/KOLs at conferences
• Consult when/if asked by Clinical Operations on any aspect of the study and/or program

Minimum Requirements

• Advanced Degree in scientific/life-sciences field with a Master’s, PharmD, or Ph.D., degree level preferred, but candidates with an RN, BSN, or other undergraduate degree with sufficient experience in similar roles will be considered.
• Large, global, late-stage Oncology Drug Development (P3) experience required.
• 6 - 8 years of experience in research with at least 4+ years of drug development experience required.
• Global oncology trial experience and Health Authority submission experience are highly preferred
• Prior experience working in a small, start-up biotech work environment preferred.
• Excellent written and oral communication skills
• Strong analytical and strategic ability
• Ability to work independently and to multi-task large projects or compounds, ability to change pace and tasks as needed, and to work in a fast-paced environment
• Knowledge of good clinical practice (GCP), FDA and EMEA/CHMP regulations, and ICH guidelines
• Ability to manage direct reports a plus
• Have proven ability to collaborate and communicate effectively in a fast-paced environment.
• Ability to accommodate up to 20% travel or as business dictates

Pay Range and Benefits:

Base Salary Range: $279,411 - $307,535 USD

Individual compensation will be determined based on factors such as work location, skills, education, training, and experience.

What we offer US-based Employees:

• Competitive base, bonus, new hire and ongoing equity packages
• The starting compensation range(s) for this role is for a full-time employee (FTE) basis
• Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment
• Employer-paid Medical, dental, and vision insurance
• Employer-paid life insurance, AD&D, short-term disability, long-term disability, and EAP coverage
• 401(k) Plan with a fully vested company match 1:1 up to 4% of contributions
• Employee Stock Purchase Plan
• 14 -18 paid holidays, including office closure between December 25th and January 1st
• Flexible vacation
• Sick time
• Fitness Program
• Get Outdoors Program
• Paid parental leave benefit
• Tuition assistance

Job Type: Full-Time

Work authorization: United States (Required)

Work Location: Remote flexibility with periodic in-person collaboration

Equal Opportunity Employer: Tyra Biosciences, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party Agencies: The Talent Acquisition team manages the recruitment and employment process for Tyra. To protect the interests of all parties involved, Tyra will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Tyra employees directly in an attempt to present candidates. Tyra will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.