Tyra Biosciences, Inc. is seeking an Associate Director of Clinical Pharmacology to play a pivotal role in advancing programs aimed at transforming patient outcomes in areas of high unmet medical need.

We are looking for someone who is strategic, scientifically rigorous, highly organized, and energized by the pace and impact of a growing, cross-functional biotech environment. In this role, you will lead clinical pharmacology and pharmacometrics strategies across multiple programs—both early- and late-stage assets. You will serve as a trusted scientific partner and communicator, representing clinical pharmacology internally and externally.

Responsibilities

• Lead and execute clinical pharmacology and pharmacometrics strategies from IND through late-stage development, ensuring scientific excellence and strategic alignment across programs.
• Design and oversee PK, population PK/PD, exposure–response, and PBPK modeling efforts to drive data-informed dose selection, study design, and critical development decisions.
• Design clinical pharmacology studies—including FIH healthy volunteer studies, human AME, bioavailability, food-effect, DDI, and organ impairment studies—with a focus on scientific rigor and operational feasibility.
• Ensure robust bioanalytical strategies, assay validation, and high-quality PK data generation, interpretation, and communication.
• Clearly and effectively communicate clinical pharmacology and modeling results—including implications and recommendations—to senior leadership, regulatory agencies, and key external collaborators.
• Author, review, and lead clinical pharmacology components of regulatory documents (INDs, IBs, CTAs, briefing packages, and responses to regulatory authority questions).
• Collaborate seamlessly with Clinical Development, Translational Sciences, Biometrics, CMC, and Preclinical teams to integrate data and guide dose selection and overall development strategy.
• Contribute to program planning, risk assessment, portfolio prioritization, and identification of process and operational improvements.
• Stay current with evolving regulatory expectations, scientific advances, and state-of-the-art modeling and simulation tools to bring forward innovative solutions.

Minimum Requirements

• PhD or PharmD in Clinical Pharmacology, Pharmaceutical Sciences, or a related quantitative discipline (e.g., engineering, applied math, computational sciences).
• Minimum of 3–4 years of industry experience in clinical pharmacology and/or pharmacometrics; oncology or rare disease experience preferred.
• Demonstrated ability to develop and implement innovative dosing and clinical pharmacology study strategies.
• Hands-on experience with NCA, population PK/PD, exposure–response, and/or PBPK modeling preferred.
• Strong understanding of bioanalytical assay development and PK characterization preferred.
• Proficiency with Phoenix WinNonlin, NONMEM, MATLAB, or related pharmacometrics tools.
• Strong knowledge of clinical pharmacology regulatory guidelines and expectations.
• Proven ability to operate with urgency, communicate clearly, and make sound decisions in a fast-paced biotech environment.
• Exceptional communication and presentation skills, with the ability to influence and collaborate across teams and levels.
• Self-motivated, proactive, and passionate about contributing to a growing startup environment.
• Demonstrated ability to navigate shifting priorities, take initiative, and step beyond defined responsibilities when needed.
• Strong organizational and multitasking skills, with willingness to travel approximately 10%.

Pay range and compensation package

• $174,000 - $224,183 USD
• Stock Options
• Full medical, dental and vision benefits
• 401k company match on the first 4% of contributions
• Employee Stock Purchase Plan
• Many more including Disability, Pet, Fitness, Education, etc.

Equal Opportunity Statement

As an equal opportunity employer, Tyra Biosciences is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws.