Tyra Biosciences, Inc. is seeking an Associate Director of DMPK/Clinical Pharmacology to play a pivotal role in advancing programs aimed at transforming patient outcomes in areas of high unmet medical need.

We are looking for someone who is scientifically rigorous, highly organized, and energized by the pace, problem-solving, and impact of a rapidly growing, cross-functional biotech environment. In this influential role, you will lead DMPK and clinical pharmacology strategy across multiple programs—both early- and late-stage assets. You will serve as a trusted scientific partner and communicator, representing clinical pharmacology internally and externally. You will collaborate proactively with internal teams to accelerate drug candidates from discovery through the clinic.

Job Responsibilities

• Lead and execute DMPK/clinical pharmacology strategies from IND through late-stage development, ensuring scientific excellence, strategic alignment across programs.
• Manage outsourced DMPK studies with CROs, ensuring scientific rigor, operational excellence, and timely delivery of results.
• Design, oversee, and interpret in vitro/in vivo ADME, PK, and drug–drug interaction (DDI) studies; predict human PK, assess safety margins, evaluate DDI risk, and provide data-driven recommendations to inform clinical study protocols and regulatory submissions (IND, NDA, EOP2).
• Design and lead translational PK/PD and PBPK modeling to support dose selection, schedule optimization, first-in-human (FIH) study design (patients and healthy volunteers), and key development decisions.
• Design and execute clinical pharmacology studies—including FIH, human AME, bioavailability, food-effect, DDI, and organ-impairment studies—with a focus on scientific rigor, quality, and operational feasibility.
• Ensure robust bioanalytical strategies, method development and validation, and high-quality PK data generation, integration, and interpretation.
• Clearly and effectively communicate DMPK/clinical pharmacology results—including modeling insights, implications, and recommendations—to senior leadership, regulatory authorities, and external collaborators.
• Partner seamlessly with Preclinical Pharmacology/Toxicology, CMC, Medicinal Chemistry, Clinical Development, Translational Sciences, and Biometrics to integrate data and guide dose selection and overall development strategy.
• Contribute to program planning, risk assessment, portfolio prioritization, and identification of process and operational improvements that enhance efficiency and scientific impact.
• Maintain up-to-date knowledge of evolving regulatory expectations, scientific advances, and emerging methodologies to drive innovation.

Minimum Requirements

• PhD in Pharmaceutical Sciences, Clinical or Quantitative Pharmacology, Drug Metabolism, or related quantitative discipline (e.g., engineering, applied math, computational sciences).
• Minimum of 3–4 years of industry experience in development DMPK and/or clinical pharmacology; oncology or rare disease experience preferred.
• Expertise in bioanalytical method development/validation and familiarity with regulatory requirements (e.g., ICH M10) preferred.
• Hands-on experience with non-compartmental analysis (NCA) or PBPK modeling for DDI assessment preferred.
• Strong knowledge of DMPK/clinical pharmacology regulatory guidelines and expectations.
• Proven ability to operate with urgency, communicate clearly, and make sound decisions in a fast-paced biotech setting.
• Exceptional communication and presentation skills, with the ability to influence, collaborate, and build strong partnerships across functions and levels.
• Self-motivated, proactive, and passionate about contributing to a growing, entrepreneurial environment.
• Demonstrated ability to navigate shifting priorities, take initiative, and step beyond defined responsibilities when needed.
• Strong organizational and multitasking skills, with willingness to travel approximately 10%.

Pay Range and Benefits:

Salary: $192,591 - $214,893 USD

The starting pay rate is a guideline, and final individual compensation will vary based on factors such as qualifications, skill level, competencies, and internal equity.

What we offer US-based Employees:

• Competitive base, bonus, new hire and ongoing equity packages
• The starting compensation range(s) for this role is for a full-time employee (FTE) basis
• Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment
• Employer-paid Medical, dental, and vision insurance
• Employer-paid life insurance, AD&D, short-term disability, long-term disability, and EAP coverage
• 401(k) Plan with a fully vested company match 1:1 up to 4% of contributions
• Employee Stock Purchase Plan
• 14 -18 paid holidays, including office closure between December 25th and January 1st
• Flexible vacation
• Sick time
• Fitness Program
• Get Outdoors Program
• Paid parental leave benefit
• Tuition assistance

Job Type: Full-Time

Work authorization: United States (Required)

Work Location: Remote flexibility with periodic in-person collaboration

Equal Opportunity Employer: Tyra Biosciences, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party Agencies: The Talent Acquisition team manages the recruitment and employment process for Tyra. To protect the interests of all parties involved, Tyra will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Tyra employees directly in an attempt to present candidates. Tyra will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.