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VP and Head of Immuno-oncology and Translational Sciences

Trishula Therapeutics

Trishula Therapeutics

Posted on Tuesday, October 3, 2023

VP and Head of Immuno-oncology and Translational Sciences

Department: Research and Development
Reports to: CEO
Status: Full Time
Location: Remote-SF Bay Area Based

Trishula Therapeutics is a clinical stage biotechnology company developing a first-in-class anti-CD39 antibody in cancer. The Company has completed Phase 1/1b clinical study in ~250 patients in various solid tumors. In partnership with AbbVie, Trishula is working to initiate a biomarker-driven randomized Phase 2 clinical study in 2023. The clinical studies have significant translational component both in peripheral and central compartment.

Position Overview:

The Vice President, and Head Immuno-oncology and Translational Sciences, leads the advancement of Trishula’s products in clinical development, with a focus on development of biomarkers, predictive diagnostics, immunohistochemistry, and probing treatment-based changes at molecular, genetic and cellular level.

Essential duties and responsibilities include but are not limited to the following:

  • Play a key role as the leader of the Translational Science Team.
  • Lead science-based design of translational efforts in one or more clinical studies.
  • Lead molecule, pathway and disease area strategies in partnership with development team to provide decision analysis and other analytic and strategic support.
  • Be accountable for leading the development of strategic plans for pipeline assets and implementation.
  • Serve as an effective team leader on product teams and for programs in the pipeline who can define the correlative science strategy; Ensure that the strategy is aligned with the product’s life cycle and development plan.
  • Serve as a lead for Trishula in jointly developing and testing biomarker strategies with development partner, AbbVie.
  • Lead expert advisory board discussions, to identify, develop and implement successful product strategies and tactical plans. Develop and maintain academic collaborations.
  • Represent Translational Sciences at relevant program and portfolio decision-making committees and support business development efforts and reviewing potential assets for in-licensing.
  • Partner with functional leaders from Research, Clinical Development, Biometrics, Regulatory, Project Leadership, and others in support of the project teams and organization.
  • Represent Translational Sciences externally with respect to Advisory Boards, Regulatory Agency interactions, and research and clinical conferences.

Position Requirements and Experience:

  • MD, PhD, or MD/PhD in relevant scientific field (e.g., Immunology, Oncology).
  • At least 10 years’ related experience in biotech, or pharmaceuticals. Experience in R&D and Clinical Trials drug development is required. Experience in strategic planning and analytics is strongly desirable. Experience in management consulting, support of strategic alliances, and business development is a plus.
  • Strategic thinker with critical ability to link preclinical approaches and personalized medicine with clinical drug development.
  • Strong leadership capabilities in formulating direction and managing in a small company environment.
  • Strong publication record and communication skills.
  • Ability to participate and contribute substantively to scientific and clinical discussions with external investigators including Advisory Board/Steering Committee discussions, with Health Authorities.
  • Values-based leadership: integrity, trust and high ethical standards; Ability to build strong relationships with key internal and external stakeholders.
  • Highly skilled in interpersonal relations, good communication skills and judgment, a strong decision-maker.
  • Ability to evaluate and mitigate risks, navigate challenging situations, and present problem-solving options; Process and results oriented; Dynamic self-starter with a drive for results.
  • Motivates others to do their best; celebrates differences; team oriented.

How To Apply