Vivarium Manager, In Vivo Pharmacology
IDEAYA Biosciences
South San Francisco, CA, USA
Posted on Jan 10, 2025
IDEAYA Biosciences (NASDAQ: IDYA) is a public, clinical-stage precision medicine oncology company committed to the discovery, development, and commercialization of targeted therapeutics for patient populations with high unmet clinical needs. Our approach integrates extensive capabilities in identifying and validating translational biomarkers with small molecule drug discovery to select patient populations most likely to benefit from the therapies we are developing. We have developed an industry leading platform and pipeline in precision medicine by applying these capabilities across multiple approaches such as direct targeting of oncogenic pathways and synthetic lethality, which represents an emerging class of precision medicine targets. We believe this diversified approach will enable us to deliver the right medicine to the right patient to drive a more robust clinical response. IDEAYA has established strategic collaborations with GSK, Amgen, Pfizer, and Gilead but wholly-owns or controls its three most-advanced clinical programs and we are committed to building a best-in-industry organization to deliver our precision medicines to the people who need them.
When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use teamwork to move science forward. For more information, please see www.ideayabio.com.
Notice to Agencies and Recruiters: All open positions and candidate activity are strictly managed through Human Resources. Please note that our policy is that recruiters do not contact employees/hiring managers directly to solicit business and/or present candidates. Submission of unsolicited resumes prior to an agreement set in place between the Human Resources Department and the recruiting agency will not create any implied obligation. Please note that failure to comply with this request will be a factor in developing a professional relationship with IDEAYA Bio. Inquiries regarding developing a recruiting relationship with us, may be directed to HR@ideayabio.com
Position Summary:
IDEAYA is seeking a highly motivated and experienced Vivarium Manager to oversee the daily operations of our animal care facility and lead in vivo pharmacology studies. The ideal candidate will have demonstrated expertise in animal husbandry and in vivo techniques, along with a proven ability to design and execute independent research projects. This role requires a hands-on individual who can both supervise staff and actively participate in experimental procedures.
The Vivarium Manager will manage daily operations of vivarium and manage, lead, and perform in vivo PK, PKPD and efficacy studies in murine cancer models. They will perform and supervise in vivo pharmacology related services including animal care and husbandry duties, inspection and receipt of animals, and in vivo pharmacology procedures including dose administration in rodents, necropsy and tissue collection.
This position is based in our South San Francisco headquarter offices and required to be onsite.
What you'll do:
- Manage vivarium operations, including facility maintenance, mouse inventory and ordering, and IACUC protocol compliance
- Conduct in vivo pharmacology studies with small molecule therapeutics in murine models of cancer, including tumor cell implantation, monitoring of disease progression, tumor and body weight measurements, administration of test agents, sample collection, and maintaining study documentation.
- Write study reports and maintain ELN records.
- Contribute to the internal development of cancer models.
- Identify and resolve technical problems and drive continuous improvement of procedures.
- Evaluate vendors for new products or technologies that may enable process improvements.
- Provide technical leadership and training to other lab members.
- Ensure compliance with animal welfare regulations.
- Develop and implement standard operating procedures (SOPs) for vivarium operations and animal care.
- Maintain accurate and detailed records of all animal care and experimental procedures.
- May serve as member of IACUC.
- May supervise husbandry and weekend contractor.
- Foster a positive and collaborative work environment
Requirements:
- B.S. or M.S. in biology, physiology, pharmacology or a closely related scientific discipline with >6 years of work experience in industry utilizing preclinical cancer models.
- Experience with routine animal husbandry.
- Proficiency with xenograft models, including tumor implantations, tumor measurements, dosing of agents by multiple routes of administration (PO, IP, IV), and tissue collection and archiving.
- Excellent record-keeping, communication skills, and maintaining ELN records.
- Proficiency in Word, Excel, PowerPoint and GraphPad.
At IDEAYA Biosciences, we care about our employees and strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health and well-being benefits. The expected salary range for this role that is based in our South San Francisco, California office is $130,000 - $148,400.
The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the office location where this open position is located, the final candidates’ experience within their profession, experience in the disease areas we are striving to make an impact in as a company, length of time within the industry, educational background, and performance during the interview process.
The Company complies with all laws respecting equal employment opportunities and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position requires you to work onsite at the Company’s facilities, with partial work-from-home flexibility, and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.
Total Rewards:
Along with our inspiring mission, and highly collaborative and inclusive environment, IDEAYA offers a competitive total rewards package that reflects our pay-for-performance philosophy where employees are eligible to be considered for merit-based salary increases, company discretionary short-term incentive plan participation, and company discretionary stock option awards (based on board approval). Our comprehensive benefits package includes, but is not limited to, medical/dental/vision coverage (100% company paid for employees and 90% company paid for dependents), 401k, ESPP, and wellness programs.
IDEAYA is an equal opportunity employer. In accordance with applicable law, IDEAYA does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets.